The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
Innate immune mechanisms of mRNA vaccines
The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
documented. Liposomes are believed to largely transport drugs into inflamed joints by …
Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses
F Hellgren, A Cagigi, R Arcoverde Cerveira… - Nature …, 2023 - nature.com
Licensed rabies virus vaccines based on whole inactivated virus are effective in humans.
However, there is a lack of detailed investigations of the elicited immune response, and …
However, there is a lack of detailed investigations of the elicited immune response, and …
Computational design of mRNA vaccines
Abstract mRNA technology has emerged as a successful vaccine platform that offered a swift
response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy …
response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy …
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19
M Yu, A Charles, A Cagigi, W Christ… - Nature …, 2023 - nature.com
Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh)
cell interactions. Whether these interactions are impaired and associated with COVID-19 …
cell interactions. Whether these interactions are impaired and associated with COVID-19 …
Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques
L Huang, T Zhao, W Zhao, A Shao, H Zhao… - Emerging Microbes & …, 2024 - Taylor & Francis
Herpes zoster remains an important global health issue and mainly occurs in aged and
immunocompromised individuals with an early exposure history to Varicella Zoster Virus …
immunocompromised individuals with an early exposure history to Varicella Zoster Virus …
Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
L Marcos-Villar, B Perdiguero, S Anthiya, ML Borrajo… - npj Vaccines, 2024 - nature.com
Vaccines based on mRNA technology have revolutionized the field. In fact, lipid
nanoparticles (LNP) formulated with mRNA are the preferential vaccine platform used in the …
nanoparticles (LNP) formulated with mRNA are the preferential vaccine platform used in the …
Updated considerations for the immunopharmacological aspects of the “talented mRNA vaccines”
C Perrotta, C Fenizia, C Carnovale, M Pozzi… - Vaccines, 2023 - mdpi.com
Messenger RNA (mRNA) vaccines belong to a new class of medications, RNA therapeutics,
including both coding and non-coding RNAs. The use of mRNA as a therapy is based on the …
including both coding and non-coding RNAs. The use of mRNA as a therapy is based on the …
Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2
The immune responses to Novavax's licensed NVX-CoV2373 nanoparticle Spike protein
vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus …
vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus …