Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology

N Montenegro-Navarro, C García-Báez… - Nature …, 2023 - nature.com
Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …

Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging

NRW Cleland, SI Al-Juboori, E Dobrinskikh… - Journal of …, 2021 - Springer
Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD) and multiple sclerosis (MS), are relatively common and devastating neurological …

Common and diet-specific metabolic pathways underlying residual feed intake in fattening Charolais yearling bulls

E Jorge-Smeding, M Bonnet, G Renand, S Taussat… - Scientific Reports, 2021 - nature.com
Residual feed intake (RFI) is one of the preferred traits for feed efficiency animal breeding.
However, RFI measurement is expensive and time-consuming and animal ranking may …

Lymph node stromal cells vary in susceptibility to infection but can support the intracellular growth of Listeria monocytogenes

JS Tucker, H Khan, SEF D'Orazio - Journal of Leukocyte Biology, 2024 - academic.oup.com
Lymph node stromal cells (LNSCs) are an often overlooked component of the immune
system but play a crucial role in maintaining tissue homeostasis and orchestrating immune …

In vitro, in vivo, and in silico models of lymphangiogenesis in solid malignancies

S Bekisz, L Baudin, F Buntinx, A Noël, L Geris - Cancers, 2022 - mdpi.com
Simple Summary Lymphangiogenesis is the formation of new lymphatic vessels in
physiological conditions but has also been found to be associated with pathologies. For …

The Inhibition of the FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between …

G Morales-Guadarrama, EA Méndez-Pérez… - International Journal of …, 2023 - mdpi.com
Vasculogenic mimicry (VM), a process in which aggressive cancer cells form tube-like
structures, plays a crucial role in providing nutrients and escape routes. Highly plastic tumor …

Design and development of in-vitro co-culture device for studying cellular crosstalk in varied tissue microenvironment

P Makwana, U Modi, B Dhimmar, R Vasita - Biomaterials Advances, 2024 - Elsevier
Despite of being in different microenvironment, breast cancer cells influence the bone cells
and persuade cancer metastasis from breast to bone. Multiple co-culture approaches have …

Cancer-induced metabolic rewiring of tumor endothelial cells

J Lidonnici, MM Santoro, RE Oberkersch - Cancers, 2022 - mdpi.com
Simple Summary Angiogenesis, the formation of new blood vessels from preexisting ones, is
a complex and demanding biological process that plays an important role in physiological …

Reprogramming carbohydrate metabolism in cancer and its role in regulating the tumor microenvironment

S Adhikari, D Guha, C Mohan, S Mukherjee… - … : Implications in Cancer, 2022 - Springer
Altered metabolism has become an emerging feature of cancer cells impacting their
proliferation and metastatic potential in myriad ways. Proliferating heterogeneous tumor …

Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing

VS Bisht, K Giri, D Kumar… - Cancer Biology & Therapy, 2021 - Taylor & Francis
Tumor metastasis is the leading cause of cancer mortality, often characterized by abnormal
cell growth and invasion to distant organs. The cancer invasion due to epithelial to …