Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery
technology has shown that this approach can improve spatially confined delivery of drugs …

Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …

Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

Acoustically driven bubbles produce a range of mechanical, thermal and chemical effects
that can be exploited in drug delivery applications. Significant improvements in the targeting …

Passive cavitation detection has been an instrumental technique for measuring cavitation
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …

Specialized features of vasculature in the central nervous system greatly limit therapeutic
treatment options for many neuropathologies. Focused ultrasound, in combination with …

Image-guided monitoring of microbubble-based focused ultrasound (FUS) therapies relies
on the accurate localization of FUS-stimulated microbubble activity (ie acoustic cavitation) …

Focused ultrasound combined with microbubble for blood-brain barrier disruption (FUS-
BBBD) is a promising technique for noninvasive and localized brain drug delivery. This …