As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Abstract Interleukin-8 (CXCL8) was originally described as a chemokine whose main
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …

Interleukin-8 (IL-8, CXCL8) is a pro-inflammatory chemokine produced by various cell types
to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its …

Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor
immunity by directly influencing interactions with glycan-binding proteins (lectins) on the …

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …

Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …

In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of
polymorphonuclear leukocytes (PMNs) into the lung. Since CXCR2 ligands, including …

Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of
human tumors. Enforced centrosome amplification in vivo plays a role in tumor initiation and …

Neutrophils provide a critical line of defense in immune responses to various pathogens,
inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work …