Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

in many cell types originate from the centrosome, and why Page 1 INATURE VOL. 312 15
NOVEMBER 1984 If such properties are manifest in the cell, they have profound consequences …

The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …

Microtubules are involved in the morphogenesis of most cells and are the structural basis of
the mitotic spindle. We report here that purified centrosomes nucleate the assembly of …

We have discovered several novel features exhibited by microtubules (MTs) in migrating
newt lung epithelial cells by time-lapse imaging of fluorescently labeled, microinjected …

Much of what is currently known concerning microtubule biochemistry and physiology has
come from studies of the interaction of various plant alkaloids with microtubules. This …

Aneuploid tumor cells can arise through multipolar mitosis caused by supernumerary
centrosomes. Multipolar spindles, however, are antagonistic to cell viability. Thus, most cells …

Bovine neurotubulin has been labeled with dichlorotriazinyl-aminofluorescein (DTAF-
tubulin) and microinjected into cultured mammalian cells strains PTK1 and BSC. The fibrous …

γ-Tubulin is a centrosomal component involved in microtubule nucleation. To determine how
this molecule behaves during the cell cycle, we have established several vertebrate somatic …