Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
[HTML][HTML] Current state of Alzheimer's fluid biomarkers
JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …
heterogeneous pathophysiology. The number of people living with AD is predicted to …
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
[HTML][HTML] LATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
Impact of multiple pathologies on the threshold for clinically overt dementia
Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
Biological subtypes of Alzheimer disease: a systematic review and meta-analysis
D Ferreira, A Nordberg, E Westman - Neurology, 2020 - AAN Enterprises
Objective To test the hypothesis that distinct subtypes of Alzheimer disease (AD) exist and
underlie the heterogeneity within AD, we conducted a systematic review and meta-analysis …
underlie the heterogeneity within AD, we conducted a systematic review and meta-analysis …
[HTML][HTML] Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
M Prudencio, J Humphrey, S Pickles… - The Journal of …, 2020 - Am Soc Clin Investig
No treatment for frontotemporal dementia (FTD), the second most common type of early-
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
Spreading of pathology in neurodegenerative diseases: a focus on human studies
J Brettschneider, KD Tredici, VMY Lee… - Nature Reviews …, 2015 - nature.com
The progression of many neurodegenerative diseases is thought to be driven by the
template-directed misfolding, seeded aggregation and cell–cell transmission of …
template-directed misfolding, seeded aggregation and cell–cell transmission of …
[HTML][HTML] Dementia with Lewy bodies: an update and outlook
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …
producing progressive cognitive decline that interferes with normal life and daily activities …