Data-driven algorithms for inverse design of polymers
The ever-increasing demand for novel polymers with superior properties requires a deeper
understanding and exploration of the chemical space. Recently, data-driven approaches to …
understanding and exploration of the chemical space. Recently, data-driven approaches to …
The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection
Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance
The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
[HTML][HTML] Quantitative fragmentomics allow affinity mapping of interactomes
Human protein networks have been widely explored but most binding affinities remain
unknown, hindering quantitative interactome-function studies. Yet interactomes rely on …
unknown, hindering quantitative interactome-function studies. Yet interactomes rely on …
[HTML][HTML] Mycobacterium biofilms
MC Muñoz-Egea, A Akir, J Esteban - Biofilm, 2023 - Elsevier
The genus Mycobacterium includes some of the deadliest pathogens of History
(Mycobacterium tuberculosis, Mycobacterium leprae), but most of the species within the …
(Mycobacterium tuberculosis, Mycobacterium leprae), but most of the species within the …
Repurposed drug candidates for antituberculosis therapy
Q An, C Li, Y Chen, Y Deng, T Yang, Y Luo - European journal of medicinal …, 2020 - Elsevier
Antibiotics have been a key part of clinical treatments for more than 70 years. Long-term use
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
[HTML][HTML] Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions
Intrinsic disorder in proteins resulting in considerable variation in structure can lead to
multiple functions including multi-specificity and diverse pathologies. Protein interfaces can …
multiple functions including multi-specificity and diverse pathologies. Protein interfaces can …
[HTML][HTML] Smart nanomaterials for treatment of biofilm in orthopedic implants
Q Hong, S Huo, H Tang, X Qu, B Yue - Frontiers in Bioengineering …, 2021 - frontiersin.org
Biofilms refer to complex bacterial communities that are attached to the surface of animate or
inanimate objects, which highly resist the antibiotics or the host immune defense …
inanimate objects, which highly resist the antibiotics or the host immune defense …
[HTML][HTML] Computer-aided drug repurposing to tackle antibiotic resistance based on topological data analysis
A Tarín-Pelló, B Suay-García, J Forés-Martos… - Computers in Biology …, 2023 - Elsevier
The progressive emergence of antimicrobial resistance has become a global health problem
in need of rapid solution. Research into new antimicrobial drugs is imperative. Drug …
in need of rapid solution. Research into new antimicrobial drugs is imperative. Drug …