Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …

NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …

N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptor,
which play a central role in learning, memory, and synaptic development. NMDARs are …

NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …

Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …