New insights in prolactin: pathological implications

V Bernard, J Young, P Chanson, N Binart - Nature Reviews …, 2015 - nature.com
Prolactin is a hormone that is mainly secreted by lactotroph cells of the anterior pituitary
gland, and is involved in many biological processes including lactation and reproduction …

Minireview: extrapituitary prolactin: an update on the distribution, regulation, and functions

RJ Marano, N Ben-Jonathan - Molecular endocrinology, 2014 - academic.oup.com
Prolactin (PRL) is an important hormone with many diverse functions. Although it is
predominantly produced by lactrotrophs of the pituitary there are a number of other organs …

Peptide hormone regulation of angiogenesis

C Clapp, S Thebault, MC Jeziorski… - Physiological …, 2009 - journals.physiology.org
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

Regulation of blood vessels by prolactin and vasoinhibins

C Clapp, S Thebault, Y Macotela… - Recent Advances in …, 2015 - Springer
Prolactin (PRL) stimulates the growth of new blood vessels (angiogenesis) either directly
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …

Autocrine/paracrine roles of extrapituitary growth hormone and prolactin in health and disease: An overview

S Harvey, CG Martínez-Moreno, M Luna… - General and …, 2015 - Elsevier
Growth hormone (GH) and prolactin (PRL) are both endocrines that are synthesized and
released from the pituitary gland into systemic circulation. Both are therefore hormones and …

16K-prolactin inhibits activation of endothelial nitric oxide synthase, intracellular calcium mobilization, and endothelium-dependent vasorelaxation

C Gonzalez, AM Corbacho, JP Eiserich, C Garcia… - …, 2004 - academic.oup.com
Activation of endothelial nitric oxide synthase (eNOS) and subsequent nitric oxide
production (NO) are events that mediate the effect of important angiogenic …

Ocular angiogenesis: mechanisms and recent advances in therapy

M Rajappa, P Saxena, J Kaur - Advances in clinical chemistry, 2010 - Elsevier
Ocular angiogenesis, the formation of new blood vessels from the existing vascular tree, is
an important cause for severe loss of vision. It can occur in a spectrum of ocular disorders …

Vasoinhibins: endogenous regulators of angiogenesis and vascular function

C Clapp, J Aranda, C González, MC Jeziorski… - Trends in Endocrinology …, 2006 - cell.com
Vasoinhibins are a family of peptides derived from prolactin, growth hormone and placental
lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to …

Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?

AQ Reuwer, P Nowak‐Sliwinska… - Journal of cellular …, 2012 - Wiley Online Library
Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the
development of the mammary gland. However, it became clear over the last decade that …

[HTML][HTML] Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A–dependent eNOS inactivation

C García, J Aranda, E Arnold… - The Journal of …, 2008 - Am Soc Clin Investig
Increased retinal vasopermeability contributes to diabetic retinopathy, the leading cause of
blindness in working-age adults. Despite clinical progress, effective therapy remains a major …