New insights in prolactin: pathological implications
Prolactin is a hormone that is mainly secreted by lactotroph cells of the anterior pituitary
gland, and is involved in many biological processes including lactation and reproduction …
gland, and is involved in many biological processes including lactation and reproduction …
Minireview: extrapituitary prolactin: an update on the distribution, regulation, and functions
RJ Marano, N Ben-Jonathan - Molecular endocrinology, 2014 - academic.oup.com
Prolactin (PRL) is an important hormone with many diverse functions. Although it is
predominantly produced by lactrotrophs of the pituitary there are a number of other organs …
predominantly produced by lactrotrophs of the pituitary there are a number of other organs …
Peptide hormone regulation of angiogenesis
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
Regulation of blood vessels by prolactin and vasoinhibins
Prolactin (PRL) stimulates the growth of new blood vessels (angiogenesis) either directly
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …
Autocrine/paracrine roles of extrapituitary growth hormone and prolactin in health and disease: An overview
S Harvey, CG Martínez-Moreno, M Luna… - General and …, 2015 - Elsevier
Growth hormone (GH) and prolactin (PRL) are both endocrines that are synthesized and
released from the pituitary gland into systemic circulation. Both are therefore hormones and …
released from the pituitary gland into systemic circulation. Both are therefore hormones and …
16K-prolactin inhibits activation of endothelial nitric oxide synthase, intracellular calcium mobilization, and endothelium-dependent vasorelaxation
Activation of endothelial nitric oxide synthase (eNOS) and subsequent nitric oxide
production (NO) are events that mediate the effect of important angiogenic …
production (NO) are events that mediate the effect of important angiogenic …
Ocular angiogenesis: mechanisms and recent advances in therapy
M Rajappa, P Saxena, J Kaur - Advances in clinical chemistry, 2010 - Elsevier
Ocular angiogenesis, the formation of new blood vessels from the existing vascular tree, is
an important cause for severe loss of vision. It can occur in a spectrum of ocular disorders …
an important cause for severe loss of vision. It can occur in a spectrum of ocular disorders …
Vasoinhibins: endogenous regulators of angiogenesis and vascular function
Vasoinhibins are a family of peptides derived from prolactin, growth hormone and placental
lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to …
lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to …
Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?
AQ Reuwer, P Nowak‐Sliwinska… - Journal of cellular …, 2012 - Wiley Online Library
Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the
development of the mammary gland. However, it became clear over the last decade that …
development of the mammary gland. However, it became clear over the last decade that …
[HTML][HTML] Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A–dependent eNOS inactivation
Increased retinal vasopermeability contributes to diabetic retinopathy, the leading cause of
blindness in working-age adults. Despite clinical progress, effective therapy remains a major …
blindness in working-age adults. Despite clinical progress, effective therapy remains a major …