Lessons from a decade of individual-based models for infectious disease transmission: a systematic review (2006-2015)
Abstract Background Individual-based models (IBMs) are useful to simulate events subject
to stochasticity and/or heterogeneity, and have become well established to model the …
to stochasticity and/or heterogeneity, and have become well established to model the …
Pneumococcal vaccines: host interactions, population dynamics, and design principles
NJ Croucher, A Løchen… - Annual review of …, 2018 - annualreviews.org
Streptococcus pneumoniae (the pneumococcus) is a nasopharyngeal commensal and
respiratory pathogen. Most isolates express a capsule, the species-wide diversity of which …
respiratory pathogen. Most isolates express a capsule, the species-wide diversity of which …
Within-host dynamics shape antibiotic resistance in commensal bacteria
The spread of antibiotic resistance, a major threat to human health, is poorly understood.
Simple population-level models of bacterial transmission predict that above a certain rate of …
Simple population-level models of bacterial transmission predict that above a certain rate of …
Estimated impact of revising the 13-valent pneumococcal conjugate vaccine schedule from 2+ 1 to 1+ 1 in England and Wales: A modelling study
Background In October 2017, the United Kingdom Joint Committee on Vaccination and
Immunisation (JCVI) recommended removal of one primary dose of the 13-valent …
Immunisation (JCVI) recommended removal of one primary dose of the 13-valent …
Pathogen evolution and the immunological niche
S Cobey - Annals of the New York Academy of Sciences, 2014 - Wiley Online Library
Host immunity is a major driver of pathogen evolution and thus a major determinant of
pathogen diversity. Explanations for pathogen diversity traditionally assume simple …
pathogen diversity. Explanations for pathogen diversity traditionally assume simple …
Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae
ER Watkins, BS Penman, J Lourenço… - PLoS …, 2015 - journals.plos.org
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause
of life-threatening illness and death worldwide. Available conjugate vaccines target only a …
of life-threatening illness and death worldwide. Available conjugate vaccines target only a …
The serotype distribution among healthy carriers before vaccination is essential for predicting the impact of pneumococcal conjugate vaccine on invasive disease
S Flasche, O Le Polain de Waroux… - PLoS computational …, 2015 - journals.plos.org
Pneumococcal conjugate vaccines (PCVs) have substantially reduced morbidity and
mortality of pneumococcal disease. The impact of the 7-valent PCV on all-serotype invasive …
mortality of pneumococcal disease. The impact of the 7-valent PCV on all-serotype invasive …
Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in …
Abstract Background The World Health Organisation recommends the use of catch-up
campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to …
campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to …
Stress responses in Streptococcus species and their effects on the host
Streptococci cause a variety of diseases, such as dental caries, pharyngitis, meningitis,
pneumonia, bacteremia, endocarditis, erysipelas, and necrotizing fasciitis. The natural niche …
pneumonia, bacteremia, endocarditis, erysipelas, and necrotizing fasciitis. The natural niche …
[HTML][HTML] Seven challenges in modeling vaccine preventable diseases
Vaccination has been one of the most successful public health measures since the
introduction of basic sanitation. Substantial mortality and morbidity reductions have been …
introduction of basic sanitation. Substantial mortality and morbidity reductions have been …