Rationale for targeting complement in COVID‐19

A Polycarpou, M Howard, CA Farrar… - EMBO molecular …, 2020 - embopress.org
A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread
internationally, posing a health emergency to the global community. COVID‐19 caused by …

[HTML][HTML] The relevance of complement to virus biology

CE Blue, OB Spiller, DJ Blackbourn - Virology, 2004 - ncbi.nlm.nih.gov
Complement is a major element of the innate immune response and also serves to link
innate and adaptive immunity. It is an ancient immunological defence system that is thought …

Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils

Y Terao, M Yamaguchi, S Hamada… - Journal of Biological …, 2006 - ASBMB
Streptococcus pyogenes is an important pathogen that causes pharyngitis, sepsis, and
rheumatic fever. Cell-associated streptococcal C5a peptidase (ScpA) protects S. pyogenes …

C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay

ES Reis, H Chen, G Sfyroera, PN Monk… - The Journal of …, 2012 - journals.aai.org
The complement anaphylatoxins C3a, C5a, and desarginated C5a (C5a desArg) play critical
roles in the induction of inflammation and the modulation of innate and acquired immune …

The good and evil of complement activation in HIV-1 infection

Q Yu, R Yu, X Qin - Cellular & molecular immunology, 2010 - nature.com
The complement system, a key component of innate immunity, is a first-line defender against
foreign pathogens such as HIV-1. The role of the complement system in HIV-1 pathogenesis …

Complement and fungal pathogens: an update

C Speth, G Rambach, R Würzner, C Lass‐Flörl - Mycoses, 2008 - Wiley Online Library
Fungal infections are a serious complication in immunocompromised patients such as
human immunodeficiency virus‐infected individuals, patients with organ transplantations or …

Human monocyte‐derived dendritic cells are chemoattracted to C3a after up‐regulation of the C3a receptor with interferons

R Gutzmer, M Lisewski, J Zwirner, S Mommert… - …, 2004 - Wiley Online Library
The anaphylatoxin C3a is an important inflammatory mediator in the innate and adaptive
immune systems. Recent reports in various animal models have fostered the role of C3a in …

Complement and its role in protection and pathogenesis of flavivirus infections

P Avirutnan, E Mehlhop, MS Diamond - Vaccine, 2008 - Elsevier
The complement system is a family of serum and cell surface proteins that recognize
pathogen-associated molecular patterns, altered-self ligands, and immune complexes …

HIV associated preeclampsia: a multifactorial appraisal

T Naicker, N Govender, T Abel, N Naidoo… - International Journal of …, 2021 - mdpi.com
Introduction: This review explores angiogenesis, vascular dysfunction, the complement
system, RAAS, apoptosis and NETosis as potential pathways that are dysregulated during …

The contribution of complement protein C1q in COVID-19 and HIV infection comorbid with preeclampsia: a review

S Govender, T Naicker - International Archives of Allergy and …, 2022 - karger.com
Dysregulation in component 1q (C1q) levels is associated with weak placental development
in preeclampsia (PE). Human immunodeficiency virus infection (HIV-1) triggers the C1q …