The widespread use of molecular machines in biology has long suggested that great
rewards could come from bridging the gap between synthetic molecular systems and the …

Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Recently, we presented evidence that high mitochondrial ATP production is a new
therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the …

Dengue virus (DENV) is an arboviral disease affecting more than 400 million people
annually. Only a single vaccine formulation is available commercially and many others are …

The major cytoskeleton protein actin undergoes cyclic transitions between the monomeric G-
form and the filamentous F-form, which drive organelle transport and cell motility. This …

Circadian clocks generate slow and ordered cellular dynamics but consist of fast-moving bio-
macromolecules; consequently, the origins of the overall slowness remain unclear. We …

The heat shock protein 90 (Hsp90) is a molecular chaperone that employs the free energy of
ATP hydrolysis to control the folding and activation of several client proteins in the eukaryotic …

Hydrolysis of nucleoside triphosphate (NTP) plays a key role for the function of many
biomolecular systems. However, the chemistry of the catalytic reaction in terms of an atomic …

In this perspective article, I discuss several research topics relevant to quantum mechanical
(QM) methods in biophysical and biochemical applications. Due to the immense complexity …

F1-ATPase, the catalytic domain of ATP synthase, synthesizes most of the ATP in living
organisms. Running in reverse powered by ATP hydrolysis, this hexameric ring-shaped …