Signaling enzymes required for sperm maturation and fertilization in mammals
S Dey, C Brothag, S Vijayaraghavan - Frontiers in Cell and …, 2019 - frontiersin.org
In mammals, motility and fertilizing ability of spermatozoa develop during their passage
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …
Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins
In the male reproductive tract, the epididymis is an essential organ for sperm maturation, in
which sperm cells acquire mobility and the ability to fertilize oocytes while being stored in a …
which sperm cells acquire mobility and the ability to fertilize oocytes while being stored in a …
Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction
The male gamete is not completely mature after ejaculation and requires further events in
the female genital tract to acquire fertilizing ability, including the processes of capacitation …
the female genital tract to acquire fertilizing ability, including the processes of capacitation …
Phosphoproteomics for the identification of new mechanisms of cryodamage: the role of SPATA18 in the control of stallion sperm function
G Gaitskell-Phillips, FE Martín-Cano… - Biology of …, 2023 - academic.oup.com
Although recent research has addressed the impact of cryopreservation on the stallion
sperm proteome, studies addressing the stallion sperm phosphoproteome are lacking. In the …
sperm proteome, studies addressing the stallion sperm phosphoproteome are lacking. In the …
Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice
BY Liu, BL Zhang, DY Gao, Q Li, XY Xu… - Frontiers in …, 2022 - frontiersin.org
Occludin (OCLN) is a tight junction protein and Ocln deletion mutation causes male infertility
in mice. However, the role of OCLN in male reproductive system remains unknown. In this …
in mice. However, the role of OCLN in male reproductive system remains unknown. In this …
Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos …
R Zhang, C Liang, X Guo, P Bao, J Pei, F Wu… - Frontiers in …, 2022 - frontiersin.org
Mammalian spermatozoa are not mature after ejaculation and must undergo additional
functional and structural changes within female reproductive tracts to achieve subsequent …
functional and structural changes within female reproductive tracts to achieve subsequent …
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice
Y Tian, X Chen, J Pu, Y Liang, W Li, X Xu, X Tan… - Plos …, 2024 - journals.plos.org
Hexokinase (HK) catalyzes the first irreversible rate-limiting step in glycolysis that converts
glucose to glucose-6-phosphate. HK1 is ubiquitously expressed in the brain, erythrocytes …
glucose to glucose-6-phosphate. HK1 is ubiquitously expressed in the brain, erythrocytes …
Dual role of valosin-containing protein (VCP/p97) in mouse sperm during capacitation
M Jabloñski, FA La Spina… - …, 2024 - rep.bioscientifica.com
Valosin-containing protein (VCP; aka p97), a member of the AAA (A TPases A ssociated with
various cellular A ctivities) family, has been associated with a wide range of cellular …
various cellular A ctivities) family, has been associated with a wide range of cellular …
Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep
J Bai, G Zhou, S Hao, Y Liu, Y Guo, J Wang… - Frontiers in Cell and …, 2023 - frontiersin.org
Semen cryopreservation is a promising technology employed in preserving high-quality
varieties in animal husbandry and is also widely applied in the human sperm bank …
varieties in animal husbandry and is also widely applied in the human sperm bank …
Glycogen synthase kinase-3 regulates sperm motility and acrosome reaction via affecting energy metabolism in goats
Hyperactivation and acrosome reaction of sperm are pre-requisite steps for fertilization.
However, the hyperactivation and acrosome reaction are critically controlled through the …
However, the hyperactivation and acrosome reaction are critically controlled through the …