Tumor heterogeneity: causes and consequences
A Marusyk, K Polyak - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …
Insight into the heterogeneity of breast cancer through next-generation sequencing
HG Russnes, N Navin, J Hicks… - The Journal of …, 2011 - Am Soc Clin Investig
Rapid and sophisticated improvements in molecular analysis have allowed us to sequence
whole human genomes as well as cancer genomes, and the findings suggest that we may …
whole human genomes as well as cancer genomes, and the findings suggest that we may …
Inferring tumor progression from genomic heterogeneity
N Navin, A Krasnitz, L Rodgers, K Cook, J Meth… - Genome …, 2010 - genome.cshlp.org
Cancer progression in humans is difficult to infer because we do not routinely sample
patients at multiple stages of their disease. However, heterogeneous breast tumors provide …
patients at multiple stages of their disease. However, heterogeneous breast tumors provide …
Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
Using the technique of differential cDNA library screening, a cDNA clone was isolated from
an estrogen receptor (ER)-positive breast carcinoma cell line (MCF7) cDNA library based …
an estrogen receptor (ER)-positive breast carcinoma cell line (MCF7) cDNA library based …
[HTML][HTML] Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites
Background The humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin®) is a
new treatment modality for metastatic breast cancer, the efficacy of which is directly …
new treatment modality for metastatic breast cancer, the efficacy of which is directly …
Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms
BJ Wagner, CT DeMaria, Y Sun, GM Wilson, G Brewer - Genomics, 1998 - Elsevier
The steady-state levels of many mRNAs are determined in part by their turnover rates.
Turnover rates, in turn, are usually controlled by proteins that bindcis-acting sequence …
Turnover rates, in turn, are usually controlled by proteins that bindcis-acting sequence …
Molecular cytogenetics of primary breast cancer by CGH
M Tirkkonen, M Tanner, R Karhu… - Genes …, 1998 - Wiley Online Library
Comparative genomic hybridization (CGH) reveals DNA sequence copy number changes
that are shared among the different cell subpopulations present in a tumor and may help to …
that are shared among the different cell subpopulations present in a tumor and may help to …
Comprehensive profiling of 8p11-12 amplification in breast cancer
V Gelsi-Boyer, B Orsetti, N Cervera, P Finetti… - Molecular Cancer …, 2005 - AACR
In human carcinomas, especially breast cancer, chromosome arm 8p is frequently involved
in complex chromosomal rearrangements that combine amplification at 8p11-12, break in …
in complex chromosomal rearrangements that combine amplification at 8p11-12, break in …
Hypomethylation of pericentromeric DNA in breast adenocarcinomas
A Narayan, W Ji, XY Zhang, A Marrogi… - … journal of cancer, 1998 - Wiley Online Library
Drug‐induced DNA demethylation in normal human cells and inherited localized
hypomethylation in mitogen‐stimulated lymphocytes from patients with a rare recessive …
hypomethylation in mitogen‐stimulated lymphocytes from patients with a rare recessive …
Future medical applications of single-cell sequencing in cancer
N Navin, J Hicks - Genome medicine, 2011 - Springer
Advances in whole genome amplification and next-generation sequencing methods have
enabled genomic analyses of single cells, and these techniques are now beginning to be …
enabled genomic analyses of single cells, and these techniques are now beginning to be …