Lipid droplets and lipid mediators in viral infection and immunity

EA Monson, AM Trenerry, JL Laws… - FEMS microbiology …, 2021 - academic.oup.com
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Defining virulence genes in the dimorphic fungi

CA Rappleye, WE Goldman - Annu. Rev. Microbiol., 2006 - annualreviews.org
Most dimorphic fungal pathogens cause respiratory disease in mammals and must therefore
possess virulence mechanisms to combat and overcome host pulmonary defenses. Over the …

RNA interference in Histoplasma capsulatum demonstrates a role for α‐(1,3)‐glucan in virulence

CA Rappleye, JT Engle, WE Goldman - Molecular microbiology, 2004 - Wiley Online Library
Histoplasma capsulatum is a fungal pathogen that causes respiratory and systemic disease
by proliferating within macrophages. While much is known about histoplasmosis, only a …

Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma

AP Rogerio, C Fontanari, É Borducchi, AC Keller… - European journal of …, 2008 - Elsevier
We have shown that the ethanolic extract of Lafoensia pacari inhibits eosinophilic
inflammation induced by Toxocara canis infection, and that ellagic acid is the secondary …

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System–Tuberculosis

XY Poh, FK Loh, JS Friedland, CWM Ong - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB) remains one of the leading infectious killers in the world, infecting
approximately a quarter of the world's population with the causative organism …

[HTML][HTML] Eicosanoid pathway on host resistance and inflammation during Mycobacterium tuberculosis infection is comprised by LTB4 reduction but not PGE2 …

CA Sorgi, EM Soares, RS Rosada… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The functions of eicosanoids, a family of potent biologically active lipid mediators, are not
restricted to inflammatory responses and they also act as mediators of the pathogenesis …

Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis

AI Medeiros, A Sá-Nunes, EG Soares… - Infection and …, 2004 - Am Soc Microbiol
Leukotrienes are classical mediators of inflammatory response. New aspects of leukotriene
function have recently been described. We examine here the previously unreported role that …

Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid

AP Rogerio, C Fontanari, MCC Melo… - Journal of Pharmacy …, 2006 - academic.oup.com
Abstract Lafoensia pacari St. Hil.(Lythraceae) is used in traditional medicine to treat
inflammation. Previously, we demonstrated the anti-inflammatory effect that the ethanolic …

Targeting neutrophils for host-directed therapy to treat tuberculosis

T Dallenga, L Linnemann, B Paudyal, U Repnik… - International Journal of …, 2018 - Elsevier
M. tuberculosis is one of the prime killers from infectious diseases worldwide. Infections with
multidrug-resistant variants counting for almost half a million new cases per year are steadily …

COVID-19: Integrating the complexity of systemic and pulmonary immunopathology to identify biomarkers for different outcomes

TFC Fraga-Silva, SR Maruyama, CA Sorgi… - Frontiers in …, 2021 - frontiersin.org
In the last few months, the coronavirus disease 2019 (COVID-19) pandemic has affected
millions of people worldwide and has provoked an exceptional effort from the scientific …