[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player

M Wesseling, JHC de Poel, SCA de Jager - ESC Heart Failure, 2020 - Wiley Online Library
Heart failure is a growing health issue as a negative consequence of improved survival
upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large …

[HTML][HTML] Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

AB Vasandan, S Jahnavi, C Shashank, P Prasad… - Scientific reports, 2016 - nature.com
Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to
mediate efficient repair. To explore this facet in-depth this study evaluates the influence of …

[HTML][HTML] Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

D Jiang, F Gao, Y Zhang, DSH Wong, Q Li, H Tse… - Cell death & …, 2016 - nature.com
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate
mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We …

[PDF][PDF] iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-α yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy

Y Zhang, Z Yu, D Jiang, X Liang, S Liao, Z Zhang… - Stem cell reports, 2016 - cell.com
Mesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-
induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive …

[HTML][HTML] Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion

Y An, WJ Liu, P Xue, Y Ma, LQ Zhang, B Zhu, M Qi… - Cell death & …, 2018 - nature.com
Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial
infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent …

Hepatoprotective effect of exosomes from human-induced pluripotent stem cell–derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats

K Nong, W Wang, X Niu, B Hu, C Ma, Y Bai, B Wu… - Cytotherapy, 2016 - Elsevier
Background This study aimed to evaluate the effect of exosomes produced by human-
induced pluripotent stem cell–derived mesenchymal stromal cells (hiPSC-MSCs-Exo) on …

Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair

X Liu, X Li, W Zhu, Y Zhang, Y Hong… - Journal of cellular …, 2020 - Wiley Online Library
Accumulating evidence has shown that mesenchymal stem cell (MSC)‐derived exosomes
(exo) mediate cardiac repair following myocardial infarction (MI). Macrophage migration …

miR‐155‐5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

Y Hong, H He, G Jiang, H Zhang, W Tao, Y Ding… - Aging cell, 2020 - Wiley Online Library
Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely
reducing their beneficial effects on myocardial infarction (MI). MicroRNAs (miRNAs) play …

[HTML][HTML] Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

SZ Seyedrazizadeh, S Poosti, A Nazari… - Stem cell research & …, 2020 - Springer
Background Retinal and/or optic nerve injury is one of the leading causes of blindness due
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …