Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …
pharmacological, and medical techniques which can be implemented in the functional …
An in vivo model of functional and vascularized human brain organoids
Differentiation of human pluripotent stem cells to small brain-like structures known as brain
organoids offers an unprecedented opportunity to model human brain development and …
organoids offers an unprecedented opportunity to model human brain development and …
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful
tools to study brain development and dysfunction. However, whether organoids can …
tools to study brain development and dysfunction. However, whether organoids can …
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies,
only to fail in human trials, suggesting a pressing need to study AD in human model …
only to fail in human trials, suggesting a pressing need to study AD in human model …
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus
Q Long, D Upadhya, B Hattiangady… - Proceedings of the …, 2017 - National Acad Sciences
Status epilepticus (SE), a medical emergency that is typically terminated through
antiepileptic drug treatment, leads to hippocampus dysfunction typified by …
antiepileptic drug treatment, leads to hippocampus dysfunction typified by …
[HTML][HTML] Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy
C Lentini, M d'Orange, N Marichal, MM Trottmann… - Cell stem cell, 2021 - cell.com
Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …
Nav1. 1-overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer's disease
Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are
required for cognitive functions and disrupted in Alzheimer's disease (AD). Network …
required for cognitive functions and disrupted in Alzheimer's disease (AD). Network …
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
Grafting of neural stem cells (NSCs) derived from human induced pluripotent stem cells
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD),
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …