Noncovalent interactions are key determinants in both chemical and biological processes.
Among such processes, the hydrophobic interactions play an eminent role in folding of …

Quinazoline and/or chalcones derivatives are important targets in several areas of chemical
sciences, mainly, in the medicinal chemistry and pharmaceutical research. The purpose of …

Abstract Ethnopharmacological relevance Rhubarb (Rhei Radix et Rhizoma) is a traditional
Chinese medicine, has been used as a strong astringent in China to treat inflammation …

Citron kinase (CITK) is an AGC-family serine/threonine kinase that regulates cytokinesis.
Despite knockdown experiments implicating CITK as an anticancer target, no selective CITK …

We report an extensive “heteroarene scan” of triazine nitrile ligands of the cysteine protease
human cathepsin L (hCatL) to investigate π‐stacking on the peptide amide bond Gly67 …

In this study, a series of thieno [2, 3-d] pyrimidine derivatives were designed, synthesized
and evaluated as novel AKT1 inhibitors. In vitro antitumor assay results showed that …

Several mutations identified in phospholamban (PLN) have been linked to familial dilated
cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains …

Herein, an unprecedented non-noble-metal-catalyzed oxidation/cyclization of ene-ynamides
is developed, allowing the synthesis of diversely functionalized lactams in moderate to good …

Stacking interactions can be important enthalpic contributors to drug binding. Among the
less well‐studied stacking interactions are those occurring between an arene and the π …

Trypanothione reductase (TR) plays a key role in the unique redox metabolism of
trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas' …