The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …

Abstract LC3-associated phagocytosis (LAP) contributes to a wide range of cellular
processes and notably to immunity. The stabilization of phagosomes by the …

Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …

Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis
involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations …

Rab7–or in yeast, Ypt7p–governs membrane trafficking in the late endocytic and autophagic
pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial …

After endocytosis, diverse cargos are sorted into endosomes and directed to various
destinations, including extracellular macromolecules, membrane lipids, and membrane …

Virtually all transport events at the Golgi complex are regulated by Arf and Rab family
GTPases. Recent work has advanced our knowledge regarding the mechanisms controlling …

Pinocytosis is an important fundamental cellular process that is used by the cell to transport
fluid and solutes. Phosphoinositide 3-kinases (PI3Ks) regulate a diverse array of dynamic …