Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

Depression is caused by a change in neural activity resulting from an increase in glutamate
that drives excitatory neurons and may be responsible for the decline in the activity and …

Importance Observational studies have reported associations between antihypertensive
medication and psychiatric disorders, although the reported direction of association appears …

Multiple studies have reported a link between mental health and high blood pressure with
mixed or even contradictory findings. Here, we resolve those contradictions and further …

Importance Prescription medications are increasingly used among adults in the United
States and many have a potential for causing depression. Objectives To characterize use of …

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention
has been given to the renin–angiotensin system. In the central nervous system, angiotensin …

Objectives The association of bipolar disorder with early and excessive cardiovascular
disease was identified over a century ago. Nonetheless, the vascular‐bipolar link remains …

The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

Emotional disorders, including depression and anxiety, contribute considerably to morbidity
across the world. Depression is a serious condition and is projected to be the top contributor …

Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain.
Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects …