Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The
overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of
interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of
several conjugated compounds across the apical membrane of the hepatocyte into the bile …

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …