Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections
P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …
Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management
J Kabeerdoss, RK Pilania, R Karkhele… - Rheumatology …, 2021 - Springer
Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder
caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been …
caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been …
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …
contributing to disease, but in many cases, the related cell types/states through which genes …
Mapping single-cell data to reference atlases by transfer learning
Large single-cell atlases are now routinely generated to serve as references for analysis of
smaller-scale studies. Yet learning from reference data is complicated by batch effects …
smaller-scale studies. Yet learning from reference data is complicated by batch effects …
SARS-CoV-2 infection of the oral cavity and saliva
Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the
molecular mechanisms driving this plasticity remain unclear. Using murine organoid and …
molecular mechanisms driving this plasticity remain unclear. Using murine organoid and …
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally.
We therefore compare the properties of the mutated S protein (SG614) with the original …
We therefore compare the properties of the mutated S protein (SG614) with the original …
The protein expression profile of ACE2 in human tissues
F Hikmet, L Méar, Å Edvinsson, P Micke… - Molecular systems …, 2020 - embopress.org
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …
Local and systemic responses to SARS-CoV-2 infection in children and adults
M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …
differences between children and adults in their response to SARS-CoV-2 infection, we …
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …