Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

The antiporter system xc− imports the amino acid cystine, the oxidized form of cysteine, into
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Neurodegenerative diseases are characterized by chronic microglial over-activation and
oxidative stress. It is now beginning to be recognized that reactive oxygen species (ROS) …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and
distinct biological features compared with other well-known programmed cell death …

Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …

This review provides an overview of the biochemistry of thiol redox couples and the
significance of thiol redox homeostasis in neurodegenerative disease. The discussion is …

Microglial cells are the resident immune cells of the central nervous system. In the resting
state, microglia are highly dynamic and control the environment by rapidly extending and …