A cursed goodbye kiss from severe acute respiratory syndrome-coronavirus-2 to its pediatric hosts: multisystem inflammatory syndrome in children

F Haslak, A Gunalp, O Kasapcopur - Current Opinion in …, 2023 - journals.lww.com
Although children are likely to have a milder COVID-19 course compared with adults, MIS-C
as a postinfectious and life-threatening complication was reported in the pediatric age. After …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokine production …

The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children

M Benamar, Q Chen, J Chou, AM Julé… - The Journal of …, 2023 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients
following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas …

Emerging insights into the pathophysiology of multisystem inflammatory syndrome associated with COVID-19 in children

J Lin, AS Harahsheh, G Raghuveer, S Jain… - Canadian Journal of …, 2023 - Elsevier
Multisystem inflammatory syndrome in children (MIS-C) has emerged as a rare delayed
hyperinflammatory response to SARS-CoV-2 infection and causes severe morbidity in the …

Host genetic susceptibility underlying SARS-CoV-2-associated multisystem inflammatory syndrome in Brazilian children

CB Santos-Rebouças, RM Piergiorge… - Molecular …, 2022 - Springer
Abstract Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-
threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Multisystem inflammatory syndrome in children (MIS-C): Implications for long COVID

T Constantin, T Pék, Z Horváth, D Garan… - …, 2023 - Springer
The COVID-19 pandemic caused by the coronavirus 2 of the severe acute respiratory
syndrome (SARS-CoV-2) has significantly affected people around the world, leading to …

Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review

S Alhumaid, KM Al Mutared, Z Al Alawi, Z Sabr… - Allergy, Asthma & …, 2023 - Springer
Background Inborn errors of immunity (IEIs) are considered significant challenges for
children with IEIs, their families, and their medical providers. Infections are the most common …

Pathogenesis and preventive tactics of immune-mediated non-pulmonary COVID-19 in children and beyond

H Chi, L Chang, YC Chao, DS Lin, HW Yang… - International Journal of …, 2022 - mdpi.com
The COVID-19 pandemic has evolved to immune escape and threatened small children and
the elderly with a higher severity and fatality of non-pulmonary diseases. These life …

MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunity

M Gelzo, A Castaldo, A Giannattasio, G Scalia… - Frontiers in …, 2022 - frontiersin.org
Multisystem inflammatory syndrome in children (MIS-C) is a rare, severe complication of
COVID-19. A better knowledge of immunological, cellular, and genetic characteristics of MIS …

Macrophage activation syndrome in MIS-C

LB Gámez-González, C Murata, J García-Silva… - …, 2024 - publications.aap.org
BACKGROUND Multisystem inflammatory syndrome (MIS-C) represents a diagnostic
challenge because of its overlap with Kawasaki disease, Kawasaki disease shock …