Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

Telomerase plays a critical role in stem cell function and tissue regeneration that depends
on its ability to elongate telomeres. For nearly two decades, it turned out that TERT regulates …

Telomerase enables replicative immortality in most cancers including acute myeloid
leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in …

White and beige adipocytes in subcutaneous adipose tissue (SAT) and visceral adipose
tissue (VAT) are maintained by proliferation and differentiation of adipose progenitor cells …

Aging and age-related disorders have become one of the prominent issue of world.
Oxidative stress due to overproduction of reactive oxygen species is the most significant …

A growing body of evidence is recognizing human cytomegalovirus (HCMV) as a potential
oncogenic virus. We hereby provide the first experimental in vitro evidence for HCMV as a …

Telomerase is a reverse transcriptase that maintains telomeres length, compensating for the
attrition of chromosomal ends that occurs during each replication cycle. Telomerase is …

Currently, breast cancer appears to be the most widespread cancer in the world and the
most common cause of cancer deaths. This specific type of cancer affects women in both …