The genetic code—the language used by cells to translate their genomes into proteins that
perform many cellular functions—is highly conserved throughout natural life. Rewriting the …

Microorganisms can be equipped with synthetic genetic programs for the production of
targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of …

Although Escherichia coli has been a popular tool for plasmid construction, this bacterium
was believed to be “unsuitable” for constructing a large plasmid whose size exceeds 500 …

Background Natural life systems can be significantly modified at the genomic scale by
human intervention, demonstrating the great innovation capacity of genome engineering …

Microbes are fascinating molecular machines which can be equipped with synthetic genetic
programs that allow them to produce therapeutic molecules targeted on demand upon …

Scientific progress in fundamental biology has drastically transformed our ability to engineer
biological systems, with diverse applications in medicine and industry, from insulin and …