The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune
responses and relevance for gut diseases, have increased dramatically over the last fifteen …

Host-derived succinate accumulates in the airways during bacterial infection. Here, we show
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …

Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses
leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft …

Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

Although tuft cells were discovered over 60 years ago, their functions have long been
enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key …

Mucociliary clearance through coordinated ciliary beating is a major innate defense
removing pathogens from the lower airways, but the pathogen sensing and downstream …

Constant exposure of the airways to inhaled pathogens requires efficient early immune
responses protecting against infections. How bacteria on the epithelial surface are detected …

Highlights•Tuft cells reside in the epithelium of airway, intestinal, and urogenital tissues.•Tuft
cell receptors and effector functions are tuned in a tissue-specific manner.•Tuft cells detect …

Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …