The carboxysome is a complex, proteinaceous organelle that plays essential roles in carbon
assimilation in cyanobacteria and chemoautotrophs. It comprises hundreds of protein …

Transcription is regulated through binding factors to gene promoters to activate or repress
expression, however, the mechanisms by which factors find targets remain unclear. Using …

Fluorescent protein (FP) maturation can limit the accuracy with which dynamic intracellular
processes are captured and reduce the in vivo brightness of a given FP in fast-dividing cells …

DNA replication must cope with nucleoprotein barriers that impair efficient replisome
translocation. Biochemical and genetic studies indicate accessory helicases play essential …

Meiotic drivers bias gametogenesis to ensure their transmission into more than half the
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …

Eukaryotic cells adapt their metabolism to the extracellular environment. Downregulation of
surface cargo proteins in response to nutrient stress reduces the burden of anabolic …

How genomic DNA is organized in the nucleus is a long-standing question. We describe a
single-molecule bioimaging method utilizing super-localization precision coupled to fully …

Membrane proteins play key roles at the interface between the cell and its environment by
mediating selective import and export of molecules via plasma membrane channels. Despite …

The yeast Hsp104 protein disaggregase is often used as a reporter for misfolded or
damaged protein aggregates and protein quality control and ageing research. Observing …

Most cells adapt to their environment by switching combinations of genes on and off through
a complex interplay of transcription factor proteins (TFs). The mechanisms by which TFs …