The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

The microenvironment influences gene expression so that the behavior of a cell is largely
determined by its interactions with the extracellular matrix, neighboring cells, and soluble …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus
(Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 …

SINCE the discovery that epidermal growth factor (EGF) can accelerate opening of the
eyelids1, the EGF receptor (EGF-R) has been extensively studied and is now considered to …

Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

Anchorage and growth factor independence are cardinal features of the transformed
phenotype. Although it is logical that the two pathways must be coregulated in normal …