The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …

Highlights•PCP complexes are robust to changes in protein levels.•Complexes may exist in
a signalosome-like assembly at cell junctions.•Wnt ligands play a conserved instructive …