[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
Planar cell polarity in development and disease
MT Butler, JB Wallingford - Nature reviews Molecular cell biology, 2017 - nature.com
Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …
WNT signaling in cardiac and vascular disease
S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
[HTML][HTML] Generating cellular diversity and spatial form: Wnt signaling and the evolution of multicellular animals
There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …
Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt)
The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …
critical, evolutionarily conserved process during development and organogenesis. Analyses …
The wing imaginal disc
BK Tripathi, KD Irvine - Genetics, 2022 - academic.oup.com
The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …
the wing and most of the notum of the adult fly. The wing disc first forms during …
[HTML][HTML] Wnt signaling in adult intestinal stem cells and cancer
M Krausova, V Korinek - Cellular signalling, 2014 - Elsevier
Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …
embryonic development and it is involved in homeostasis of adult tissues. In the …
[HTML][HTML] Cell biology in development: the cell biology of planar cell polarity
D Devenport - The Journal of cell biology, 2014 - ncbi.nlm.nih.gov
Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …
[HTML][HTML] The emerging mechanisms of Wnt secretion and signaling in development
Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …
pathways. These pathways regulate crucial processes during various stages of development …
From instruction to output: Wnt/PCP signaling in development and cancer
AC Humphries, M Mlodzik - Current opinion in cell biology, 2018 - Elsevier
Highlights•PCP complexes are robust to changes in protein levels.•Complexes may exist in
a signalosome-like assembly at cell junctions.•Wnt ligands play a conserved instructive …
a signalosome-like assembly at cell junctions.•Wnt ligands play a conserved instructive …