Bone is a hard-connective tissue composed of matrix, cells and bioactive factors with a
hierarchical structure, where the matrix is mainly composed of type I collagen and …

Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of
the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration …

Low back pain affects a large portion of the population, resulting in high care costs for
therapy and treatment. One primary cause of low back pain is the degeneration of the …

Biomaterials for regeneration of the intervertebral disc must meet complex requirements
conforming to biological, mechanical and clinical demands. Currently no consensus on their …

Intervertebral disc (IVD) degeneration has been described as an aberrant, cell‐mediated,
age‐and genetics‐dependent molecular degeneration process, which can be accelerated …

Aim: To develop a biomimetic polymeric injectable hydrogel that can support nucleus
pulposus (NP) regeneration. Materials & methods: Natural polymer-based hydrogels were …

Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar
spine pathologies, amongst which chronic low back pain has become the number one …

Cell-based regenerative approaches have been suggested as primary or adjuvant
procedures for the treatment of degenerated intervertebral disc (IVD) diseases. Our aim was …

Since loss of meniscus is correlated with an increasing risk for osteoarthritis, meniscal
scaffolds are proposed as new strategies. Development of a suitable scaffold has to take into …

Intervertebral disc disease is characterized by a series of deleterious changes in cellularity
that lead to loss of extracellular matrix structure, altered biomechanical loading, and …