Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2
(PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …

A major metabolic aberration associated with cancer is a change in glucose metabolism.
Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the …

Abstract Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic
options for preventing its progression are limited. To identify novel therapeutic strategies, we …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …