Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Probing the dynamic RNA structurome and its functions
RC Spitale, D Incarnato - Nature Reviews Genetics, 2023 - nature.com
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
RNA sequencing: the teenage years
Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …
transcriptome-wide analysis of differential gene expression and differential splicing of …
Advances and opportunities in RNA structure experimental determination and computational modeling
Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …
include catalyzing biochemical reactions and regulating gene expression. Most of these …
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA
genome responsible for the ongoing COVID-19 pandemic. Although population average …
genome responsible for the ongoing COVID-19 pandemic. Although population average …
Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements
I Manfredonia, C Nithin… - Nucleic acids …, 2020 - academic.oup.com
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …
of gene expression beyond that of their sequence. In this Review, we discuss the current …
[HTML][HTML] In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
K Leppek, GW Byeon, W Kladwang… - Nature …, 2022 - nature.com
Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …