Molecular mechanisms of antibiotic resistance revisited
EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance
A Davin-Regli, JP Lavigne… - Clinical microbiology …, 2019 - Am Soc Microbiol
The genus Enterobacter is a member of the ESKAPE group, which contains the major
resistant bacterial pathogens. First described in 1960, this group member has proven to be …
resistant bacterial pathogens. First described in 1960, this group member has proven to be …
Multidrug efflux pumps: structure, function and regulation
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …
throughout the world and threaten to become untreatable. The origins of resistance are …
Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
[HTML][HTML] Challenges and opportunities in cryo-EM single-particle analysis
D Lyumkis - Journal of Biological Chemistry, 2019 - ASBMB
Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …
macromolecular objects and their assemblies. Although the techniques have been …
Molecular mechanisms of antibiotic resistance
Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly
common and are causing a global health crisis. Antibiotic resistance is encoded by several …
common and are causing a global health crisis. Antibiotic resistance is encoded by several …
Alternative ORFs and small ORFs: shedding light on the dark proteome
Traditional annotation of protein-encoding genes relied on assumptions, such as one open
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …