The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity
Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …
MHC and Evolution in Teleosts
U Grimholt - Biology, 2016 - mdpi.com
Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …
responses towards invading pathogens. Both MHC class I and class II genes are present in …
Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
TA Lehti, MI Pajunen, MS Skog, J Finne - Nature communications, 2017 - nature.com
Eukaryotic organisms are continuously exposed to bacteriophages, which are efficient gene
transfer agents in bacteria. However, bacteriophages are considered not to pass the …
transfer agents in bacteria. However, bacteriophages are considered not to pass the …
Hyperinsulinemia: A unifying theory of chronic disease?
Globally, there is an increasing prevalence of non-communicable diseases. The morbidity
and mortality from these conditions confer a greater economic societal burden …
and mortality from these conditions confer a greater economic societal burden …
Is insulin-like growth factor-1 involved in Parkinson's disease development?
I Castilla-Cortázar, GA Aguirre, G Femat-Roldán… - Journal of translational …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …
Identifying hyperinsulinaemia in the absence of impaired glucose tolerance: An examination of the Kraft database
Objective Hyperinsulinaemia is associated with development of chronic metabolic disease
and is emerging as a health risk independent to that of insulin resistance. However, little is …
and is emerging as a health risk independent to that of insulin resistance. However, little is …
Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism
KS Chen, MH Noureldein, LM McGinley… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Stem cells are a promising therapeutic in Alzheimer's disease (AD) given the
complex pathophysiologic pathways involved. However, the therapeutic mechanisms of …
complex pathophysiologic pathways involved. However, the therapeutic mechanisms of …
Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain
Polysialated neural cell adhesion molecule (PSA-NCAM) is a membrane bound
glycoprotein widely expressed during nervous system development. While commonly …
glycoprotein widely expressed during nervous system development. While commonly …
Is polysialylated NCAM not only a regulator during brain development but also during the formation of other organs?
CE Galuska, T Lütteke, SP Galuska - Biology, 2017 - mdpi.com
In mammals several cell adhesion molecules are involved during the pre-and postnatal
development of all organ systems. A very prominent member of this family is the neural cell …
development of all organ systems. A very prominent member of this family is the neural cell …
Re-expression of poly/oligo-sialylated adhesion molecules on the surface of tumor cells disrupts their interaction with immune-effector cells and contributes to …
Simple Summary The immune system consists of various mechanisms contributing to the
battle against cancer cells or hazardous pathogens. However, in cancer progression the …
battle against cancer cells or hazardous pathogens. However, in cancer progression the …