Nontranslational functions of vertebrate aminoacyl tRNA synthetases (aaRSs), which
catalyze the production of aminoacyl-tRNAs for protein synthesis, have recently been …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

How genetic information gained its exquisite control over chemical processes needed to
build living cells remains an enigma. Today, the aminoacyl-tRNA synthetases (AARS) …

Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

Mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and proliferation
by sensing fluctuations in environmental cues such as nutrients, growth factors, and energy …

The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial,
anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl …

The fidelity of aminoacylation of tRNA Thr by the threonyl-tRNA synthetase (ThrRS) requires
the discrimination of the cognate substrate threonine from the noncognate serine …

Motivation: Existing comparisons of protein structures are not able to describe structural
divergence and flexibility in the structures being compared because they focus on identifying …

S. aureus is classified as a serious threat pathogen and is a priority that guides the discovery
and development of new antibiotics. Despite growing knowledge of S. aureus metabolic …

Pyrrolysine, a lysine derivative with a bulky pyrroline ring, is the “22nd” genetically encoded
amino acid. In the present study, the carboxy-terminal catalytic fragment of Methanosarcina …