Development from fertilized egg to functioning multi-cellular organism requires precision.
There is no precision, and often no survival, without plasticity. Plasticity is conferred partly by …

The mammalian sexes are distinguished by the X and Y chromosomes. Whereas males
harbor one X and one Y chromosome, females harbor two X chromosomes. To equalize X …

The relationship between transcription and protein expression is complex. We identified
polysome-associated RNA transcripts in the somata and central terminals of mouse sensory …

Connexin32 (Cx32) is expressed in myelinating Schwann cells. It forms both reflexive gap
junctions, to facilitate transfer of molecules from the outer to the inner myelin layers and …

Changes in gene dosage can have tremendous evolutionary potential (eg whole-genome
duplications), but without compensatory mechanisms, they can also lead to gene …

Highlights•XIST first mediates dampening, then silencing of X-linked genes in human
development•Complete gene silencing on the inactive X requires chromatin …

Dosage compensation in Drosophila involves upregulating male X-genes two-fold. This
process is carried out by the MSL (male-specific lethal) complex, which binds high-affinity …

Gene expression is influenced by chromatin architecture via controlled access of regulatory
factors to DNA. To better understand gene regulation in the human dorsal root ganglion …

Developmental genes are controlled by an ensemble of cis-acting regulatory elements
(REs), which in turn respond to multiple trans-acting transcription factors (TFs) …

The capacity of cells to retain a memory of previous signals enables them to adopt unique
cell fates and adjust to their surrounding environment. The underlying gene expression …