Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Cannabis sativa L. turned out to be a valuable source of chemical compounds of various
structures, showing pharmacological activity. The most important groups of compounds …

Neuropathic pain is a chronic secondary pain condition, which is a consequence of
peripheral or central nervous (somatosensory) system lesions or diseases. It is a devastating …

Background: Pulsed radiofrequency (PRF) treatment uses low energy, short pulsations to
modulate tissue characteristics. PRF treatment has been effective as an interventional pain …

Introduction The primary objective of this paper is to (1) provide a summary of human studies
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …

Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic
complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role …

Objective: Long non-coding RNAs (lncRNAs) exert a critical function in mediating
neuropathic pain (NP). MEG3, a novel lncRNA, contributes to astrocyte activation and …

Objective To determine the prevalence of neuropathic-like pain (NP) and pain sensitization
(PS) defined by self-report questionnaires in knee and hip osteoarthritis, and whether …

Bidirectional interplay between the peripheral immune and nervous systems plays a crucial
role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is …

This study aimed to investigate the anti-neuropathic pain activity and its underlying
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …