To preserve the integrity of their genome, bacteria rely on several genome maintenance
mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a …

The replication of DNA is a complex biological process that is essential for life. Bacterial
DNA replication is initiated at genomic loci referred to as replication origins (oriC s) …

DoriC was first launched in 2007 as a database of replication origins (oriC s) in bacterial
genomes and has since been constantly updated to integrate the latest research progress in …

Although the mechanism of DNA replication initiation has been investigated for over 50
years, many important discoveries have been made related to this process in recent years …

Genome duplication is essential for the proliferation of cellular life and this process is
generally initiated by dedicated replication proteins at chromosome origins. In bacteria, DNA …

Bidirectional DNA replication from a chromosome origin requires the asymmetric loading of
two helicases, one for each replisome. Our understanding of the molecular mechanisms …

Genome replication is a fundamental biological activity shared by all organisms.
Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two …

Genome duplication is essential for cell proliferation and DNA synthesis is generally initiated
by dedicated replication proteins at specific loci termed origins. During DNA replication …

The mechanisms responsible for helicase loading during the initiation of chromosome
replication in bacteria are unclear. Here we report both a positive and a negative …