Drug toxicity evaluation is an essential process of drug development as it is reportedly
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …

Advanced biomaterials are increasingly used for numerous medical applications from the
delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The …

The exponential increase in our ability to harness multi-dimensional biological and clinical
data from experimental to real-world settings has transformed pharmaceutical research and …

Abstract 'Cell Painting'is an imaging-based high-throughput phenotypic profiling (HTPP)
method in which cultured cells are fluorescently labeled to visualize subcellular structures …

The renal proximal tubule is responsible for re-absorption of the majority of the glomerular
filtrate and its proper function is necessary for whole-body homeostasis. Aging, certain …

Antisense oligonucleotides (ASOs) are a promising therapeutic modality. However, failure to
predict acute kidney injury induced by SPC5001 ASO observed in a clinical trial suggests …

In recent years, drug‐induced nephrotoxicity has been one of the main reasons for the
failure of drug development. Early prediction of the nephrotoxicity for drug candidates is …

Drug induced kidney injury (DIKI) is a common reason for compound attrition in drug
development pipelines with proximal tubule epithelial cells (PTECs) most commonly …

Toxicology aims to comprehend and envisage the adverse outcomes of chemicals and
xenobiotics on the biological system. Predicting toxicity on the biological system is a …

Emerging data indicate that structural analogs of bisphenol A (BPA) such as bisphenol S
(BPS), tetrabromobisphenol A (TBBPA), and bisphenol AF (BPAF) have been introduced …