Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …

Regulation of mRNA translation, the process by which ribosomes decode mRNAs into
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …

In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

Translation regulation is critical for early mammalian embryonic development. However,
previous studies had been restricted to bulk measurements, precluding precise …

Pre-implantation embryo development is an intricate and precisely regulated process
orchestrated by maternally inherited proteins and newly synthesized proteins following …

To better understand the gene regulatory mechanisms that program developmental
processes, we carried out simultaneous genome-wide measurements of mRNA, translation …

Regulation of protein synthesis is a vital step in controlling gene expression, especially
during development. Over the last 10 years, it has become clear that rather than being …

The function of normal and defective candidate genes for human genetic diseases, which
are rapidly being identified in large numbers by human geneticists and the biomedical …

Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual
cells. This Feature highlights recent developments in key analytical techniques suited for …