Induction of DNA damage by UVB and UVA radiation may generate mutations and genomic
instability leading to carcinogenesis. Therefore, skin cells being repeatedly exposed to …

Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular
response to HS utilizes ancient molecular networks that are based primarily on the action of …

Simple Summary Many clinical trials have shown benefit for adding hyperthermia (heat)
treatment to radiotherapy. Despite overall success, some patients do not derive maximum …

Hyperthermia is a promising treatment modality for cancer in combination both with radio-
and chemotherapy. In spite of its great therapeutic potential, the underlying molecular …

Purpose: From the role of double strand DNA dependent protein kinase (DNA-PKcs) activity
of non-homologous end joining (NHEJ) repair for DNA double strand breaks (DSBs), we aim …

H2AX is a histone variant which is present and ubiquitously distributed throughout the
genome. An immunocytochemical assay using antibodies capable of recognizing histone …

We investigated antitumor, genotoxic, chemopreventive, and immunostimulative effects of
local chemoimmunotherapy and hyperthermal intraperitoneal chemotherapy (HIPEC) in a …

Local application of hyperthermia has a myriad of effects on the tumor microenvironment as
well as the host's immune system. Ablative hyperthermia (typically> 55° C) has been used …

In eukaryotes, the ubiquitin–proteasome system (UPS) is responsible for the degradation of
most proteins. Proteasome inhibition, which has been associated with various diseases, can …

The role of the Fanconi anemia (FA) repair pathway for DNA damage induced by
formaldehyde was examined in the work described here. The following cell types were used …