Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Our knowledge of the pathophysiology of affect dysregulation has progressively increased,
but the pharmacological treatments remain inadequate. Here, we summarize the current …
but the pharmacological treatments remain inadequate. Here, we summarize the current …
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression
Background Evidence continues to build suggesting that the GABAergic neurotransmitter
system is altered in brains of patients with major depressive disorder. However, there is little …
system is altered in brains of patients with major depressive disorder. However, there is little …
Npas1+-Nkx2. 1+ neurons are an integral part of the cortico-pallido-cortical loop
ZA Abecassis, BL Berceau, PH Win… - Journal of …, 2020 - Soc Neuroscience
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in
motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established …
motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established …
Binaural blood flow control by astrocytes: listening to synapses and the vasculature
A Mishra - The Journal of physiology, 2017 - Wiley Online Library
Astrocytes are the most common glial cells in the brain with fine processes and endfeet that
intimately contact both neuronal synapses and the cerebral vasculature. They play an …
intimately contact both neuronal synapses and the cerebral vasculature. They play an …
Nitric oxide signalling in the brain and its control of bodily functions
K Chachlaki, V Prevot - British journal of pharmacology, 2020 - Wiley Online Library
Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival
of mammalian species by endowing brain neuronal networks with the ability to make …
of mammalian species by endowing brain neuronal networks with the ability to make …
Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits
L Tricoire, T Vitalis - Frontiers in neural circuits, 2012 - frontiersin.org
Nitric oxide (NO) is an important signaling molecule crucial for many physiological
processes such as synaptic plasticity, vasomotricity, and inflammation. Neuronal nitric oxide …
processes such as synaptic plasticity, vasomotricity, and inflammation. Neuronal nitric oxide …
Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression
Somatostatin (SST), a neuropeptide expressed in dendritic-targeting gamma-aminobutyric
acid (GABA) neurons, is decreased across corticolimbic areas in major depressive disorder …
acid (GABA) neurons, is decreased across corticolimbic areas in major depressive disorder …
The chandelier cell, form and function
M Inan, SA Anderson - Current opinion in neurobiology, 2014 - Elsevier
Highlights•Chandelier cells (ChCs) have specific spatial and temporal origins.•ChCs can
depolarize or hyperpolarize the pyramidal cell based on its resting membrane …
depolarize or hyperpolarize the pyramidal cell based on its resting membrane …
Biological substrates underpinning diagnosis of major depression
Major depression is characterized by low mood, a reduced ability to experience pleasure
and frequent cognitive, physiological and high anxiety symptoms. It is also the leading cause …
and frequent cognitive, physiological and high anxiety symptoms. It is also the leading cause …