Prognostic biomarkers of cell proliferation in colorectal cancer (CRC): from immunohistochemistry to molecular biology techniques

A Kasprzak - Cancers, 2023 - mdpi.com
Simple Summary This review aims to shed light on the proliferative markers important in the
everyday clinical management of colorectal cancer (CRC), ranging from simple methods of …

Management of early rectal cancer

MG Tytherleigh, BF Warren… - Journal of British …, 2008 - academic.oup.com
Background Early rectal cancer (ERC) is adenocarcinoma that has invaded into, but not
extended beyond, the submucosa of the rectum (that is a T1 tumour). Local excision is …

Prognostic significance of the wnt signalling pathway molecules APC, β‐catenin and E‐cadherin in colorectal cancer—a tissue microarray‐based analysis

A Lugli, I Zlobec, P Minoo, K Baker, L Tornillo… - …, 2007 - Wiley Online Library
Aims: To investigate dysregulation of the wnt signalling pathway by assessing β‐catenin
expression/increasing expression and loss of cytoplasmic adenomatous polyposis coli …

Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: evidence from meta-analysis

X He, Z Chen, M Jia, X Zhao - PloS one, 2013 - journals.plos.org
Background Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression
and aggressiveness of colorectal carcinoma. E-cadherin is the best-characterized molecular …

L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer

YJ Boo, JM Park, J Kim, YS Chae, BW Min… - Annals of surgical …, 2007 - Springer
Background L1, a new target gene for Wnt/β-catenin–TCF signaling, has been identified in
the invasive front of colorectal cancer cells in vitro study. The L1 molecule is localized on the …

The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry

ECM Zeestraten, A Benard, MS Reimers… - Biomarkers in …, 2013 - journals.sagepub.com
Research towards biomarkers that predict patient outcome in colorectal cancer (CRC) is
rapidly expanding. However, none of these biomarkers have been recommended by the …

CD133 identifies perivascular niches in grade II–IV astrocytomas

K Christensen, HD Schrøder, BW Kristensen - Journal of neuro-oncology, 2008 - Springer
The aim of the present study was to investigate the localization and distribution of the
putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded …

Elevated expression of E-cadherin and α-, β-, and γ-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas

T Imai, A Horiuchi, T Shiozawa, R Osada, N Kikuchi… - Human pathology, 2004 - Elsevier
E-cadherin and catenins play key roles in cell adhesion and motility. Little is known about
the changes in expression of these molecules in the progression of ovarian carcinomas. In …

Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

C Magnusson, M Mezhybovska, E Lörinc… - European Journal of …, 2010 - Elsevier
Colorectal cancer is the third most common cancer type in the Western world. In search of
new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes …

β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis

Z Chen, X He, M Jia, Y Liu, D Qu, D Wu, P Wu, C Ni… - PLoS …, 2013 - journals.plos.org
Background β-catenin plays a key role in the progression of colorectal cancer (CRC).
However, its prognostic significance for patients with CRC remains controversial …