New drug production, from target identification to marketing approval, takes over 12 years
and can cost around $2.6 billion. Furthermore, the COVID-19 pandemic has unveiled the …

Conspectus In structure-based drug design, scoring functions are widely used for fast
evaluation of protein–ligand interactions. They are often applied in combination with …

Developing new drugs is too expensive and time-consuming. Accurately predicting the
interaction between drugs and targets will likely change how the drug is discovered …

The study of protein-protein interaction is of great biological significance, and the prediction
of protein-protein interaction sites can promote the understanding of cell biological activity …

Background Previous studies have reported that transplantation of mesenchymal stem cells
(MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study …

Carbohydrate-binding proteins play significant roles in many diseases including cancer.
Here, we established a machine-learning-based method (called sequence-based prediction …

In the field of medicinal chemistry there is increasing focus on identifying key proteins whose
biochemical functions can firmly be linked to serious diseases. Such proteins become …

Interaction of low-density lipoprotein receptors with proprotein convertase subtilisin/kexin
type 9 (PCSK9) plays a vital part in causing atherosclerosis. It is the hidden precursor of …

Biopolymeric continuous core‐sheath fibres, with an inner core of chitosan and alginate as
the sheath, were fabricated for the first time without using a template. Hereby, the necessary …

Hispolon is a polyphenolic compound derived from black hoof mushroom (Phellinus linteus)
or shaggy bracket mushroom (Inonotus hispidus) which induces the inhibition of cancer …