▪ Abstract The transcription factor NF-κB has attracted widespread attention among
researchers in many fields based on the following: its unusual and rapid regulation, the wide …

Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …

NF-κB in defense and disease ciated with inflammatory disease. Indeed, as discussed by
Tak and Firestein (this Perspective series), NF-κB is activated in the inflamed synovium of …

A major advance in the understanding of NF-κB regulation came with the identification of the
multisubunit IKK kinase complex, which contains two catalytic subunits, IKK-α and IKK-β …

The novel protein kinase C (PKC) isoform, PKCθ, is selectively expressed in T lymphocytes
and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells …

MURR1 is a multifunctional protein that inhibits nuclear factor κB (NF-κB), a transcription
factor with pleiotropic functions affecting innate and adaptive immunity, apoptosis, cell cycle …

The human immunodeficiency virus type 1 (HIV) Tat protein, a potent activator of HIV gene
expression, is essential for integrated viral genome expression and represents a potential …

Bioluminescence refers to the process of visible light emission in living organisms.
Bioluminescence imaging is a powerful methodology that has been developed over the last …

The pathogenesis of HIV infection, and in particular the development of immunodeficiency,
remains incompletely understood. Whichever intricate molecular mechanisms are at play …

CD4+ T lymphocytes represent the main target cell population of human immunodeficiency
virus (HIV). In an activated state, CD4+ T cells residing in lymphoid organs are a major …