Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

M Masoodi, A Gastaldelli, T Hyötyläinen… - Nature reviews …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …

Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Role of insulin resistance in MAFLD

Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

MP Moore, RP Cunningham, GM Meers… - …, 2022 - Wiley Online Library
Background and Aims NAFLD and its more‐advanced form, steatohepatitis (NASH), is
associated with obesity and is an independent risk factor for cardiovascular, liver‐related …

Metabolic and signaling roles of ketone bodies in health and disease

P Puchalska, PA Crawford - Annual review of nutrition, 2021 - annualreviews.org
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA

J Ngo, DW Choi, IA Stanley, L Stiles, AJA Molina… - The EMBO …, 2023 - embopress.org
Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways

S Amjad, S Nisar, AA Bhat, MP Frenneaux, K Fakhro… - Molecular …, 2021 - Elsevier
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics

P Puchalska, PA Crawford - Cell metabolism, 2017 - cell.com
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …