Chronic wasting disease in Europe: new strains on the horizon

MA Tranulis, D Gavier-Widén, J Våge… - Acta Veterinaria …, 2021 - Springer
Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

K Moazami-Goudarzi, O Andréoletti, JL Vilotte… - Veterinary …, 2021 - Springer
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting
several captive, free ranging and wild cervid species. Responsible for marked population …

Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD

S Hannaoui, I Zemlyankina, SC Chang, MI Arifin… - Acta …, 2022 - Springer
Prions cause infectious and fatal neurodegenerative diseases in mammals. Chronic wasting
disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed …

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice …

J Bian, S Kim, SJ Kane, J Crowell, JL Sun… - Plos …, 2021 - journals.plos.org
Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of
animals and humans. Replication involves template-directed refolding of host encoded prion …

The Zoonotic Potential of Chronic Wasting Disease—A Review

MA Tranulis, M Tryland - Foods, 2023 - mdpi.com
Prion diseases are transmissible neurodegenerative disorders that affect humans and
ruminant species consumed by humans. Ruminant prion diseases include bovine …

North American and Norwegian chronic wasting disease prions exhibit different potential for interspecies transmission and zoonotic risk

S Pritzkow, D Gorski, F Ramirez… - The Journal of …, 2022 - academic.oup.com
Background Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting
various species of wild and captive cervids. The risk that CWD poses to cohabiting animals …

Transgenic mouse models for the study of neurodegenerative diseases

A Marín-Moreno, S Canoyra… - … de Investigación en …, 2023 - digital.csic.es
Neurodegenerative diseases (NDs) are some of the most important health challenges
modern medicine and advanced societies face. Indeed, the number of patients affected by …

Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity

SC Chang, MI Arifin, W Tahir, KJ McDonald… - PLoS …, 2024 - journals.plos.org
Prions can exist as different strains that consist of conformational variants of the misfolded,
pathogenic prion protein isoform PrPSc. Defined by stably transmissible biological and …

Chronic wasting disease (CWD) in cervids and the consequences of a mutable protein conformation

CJ Silva - ACS omega, 2022 - ACS Publications
Chronic wasting disease (CWD) is a prion disease of cervids (deer, elk, moose, etc.). It
spreads readily from CWD-contaminated environments and among wild cervids. As of 2022 …

Monitoring of chronic wasting disease (CWD)(IV)

EFSA Panel on Biological Hazards (BIOHAZ)… - EFSA …, 2023 - Wiley Online Library
Abstract The European Commission requested an analysis of the Chronic Wasting Disease
(CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia …