Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Arynes and donor–acceptor (D–A) cyclopropanes are two classes of strained systems
having the potential for numerous applications in organic synthesis. The last two decades …

Small-ring heterocycles have found many applications both as useful starting materials in
the synthesis of more elaborate structures and as valuable targets of synthesis. Our review …

1. INTRODUCTION Within 14 years of the seminal experiments of JD Roberts leading to the
first proposal of the structure of benzyne (1), 1 synthetic organic chemists recognized the …

This tutorial review is aimed at highlighting recent developments in transition-metal-free
carbon–carbon and carbon–heteroatom bond-forming reactions utilizing a versatile class of …

About two decades after Kobayashi's discovery in 1983 of a very mild way of generating
highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl) aryl …

Abstract ortho‐Quinone methides (o‐QMs) are emerging as highly useful intermediates, the
inherent reactivity of which can be used in linchpin reactions for the construction of complex …

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates,
advancing the construction of complex molecular frameworks. Employing multiple …

The Direct Acyl-Alkylation of Arynes | Journal of the American Chemical Society ACS ACS
Publications C&EN CAS Find my institution Log In Journal of the American Chemical Society …

Arynes are neutral intermediates in which two adjacent atoms of an aromatic ring lack
substituents, thus leaving two atomic orbitals (perpendicular to the aromatic x system) to …