Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia—from molecular mechanisms to clinical relevance

R Alves, AC Gonçalves, S Rutella, AM Almeida… - Cancers, 2021 - mdpi.com
Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …

[HTML][HTML] Ophthalmologic manifestations as the initial presentation of chronic myeloid leukemia: a review

MA Yassin, F Ata, SF Mohamed, A Alkhateeb… - survey of …, 2022 - Elsevier
The presentation of chronic myeloid leukemia (CML) can be variable and related to the
phase of the disease. It can manifest a wide range of symptoms and signs; ocular …

Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies

S Younes, MA Ismail, R Al-Jurf, A Ziyada… - …, 2023 - Taylor & Francis
Small molecule therapy is a critical component of targeted anticancer treatment, with
tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic …

Association between adherence to oral therapies in cancer patients and clinical outcome: A systematic review of the literature

R Lasala, F Santoleri - British Journal of Clinical Pharmacology, 2022 - Wiley Online Library
Aims Adherence to therapy is a key factor in successful treatment. The aim of this systematic
review is to assess the extent to which patients with better adherence to oral therapy have …

Efficacy of a medication management service in improving adherence to tyrosine kinase inhibitors and clinical outcomes of patients with chronic myeloid leukaemia: a …

BK Tan, SS Chua, LC Chen, KM Chang… - Supportive Care in …, 2020 - Springer
Purpose Suboptimal adherence to tyrosine kinase inhibitors (TKIs) contributes to poor
clinical outcomes in chronic myeloid leukemia (CML). This randomised controlled trial (RCT) …

Needs for information and reasons for (non) adherence in chronic myeloid leukaemia: Be aware of social activities disturbing daily routines

CCLM Boons, L Harbers, L Timmers… - European journal of …, 2018 - Wiley Online Library
Objectives To obtain insight into patients' reasons for medication (non) adherence in chronic
myeloid leukaemia (CML) and needs and wishes regarding information and communication …

Natural history, with clinical, biochemical, and molecular characterization of classical homocystinuria in the Qatari population

N Al‐Dewik, A Ali, Y Mahmoud… - Journal of Inherited …, 2019 - Wiley Online Library
Classical homocystinuria (HCU) is the most common inborn error of metabolism in Qatar,
with an incidence of 1: 1800, and is caused by the Qatari founder p. R336C mutation in the …

Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients

MA Ismail, M Vezzalini, H Morsi, A Abujaber… - Scientific Reports, 2021 - nature.com
Protein tyrosine phosphatase receptor gamma (PTPRG) is a member of the receptor-like
family protein tyrosine phosphatases and acts as a tumor suppressor gene in different …

Assessment of dasatinib versus nilotinib as upfront therapy for chronic phase of chronic myeloid leukemia in Qatar: a cost-effectiveness analysis

A Adel, D Abushanab, A Hamad, M Abdulla… - Cancer …, 2021 - journals.sagepub.com
Background: The economic outcome research of approved tyrosine kinase inhibitors for
treating the chronic phase of chronic myeloid leukemia in developing is scarce. The aim of …

[PDF][PDF] Imatinib mesylate adherence in chronic myeloid leukemia patients: Data from middle euphrates region of Iraq

A Mjalia, SK Abbasb - Higher education, 2021 - researchgate.net
Background: Chronic myeloid leukemia (CML) represents about one quarter of leukemia
cases in our region making it a great challenge to the health system. Aims: Since adherence …